Synthesis, characterization and cytotoxicity Study of 2- (benzylideneamino)-3-methylbutanoic acid and its coordination compounds

Abstract

The Schiff base 2-(benzylideneamino)-3-methylbutanoic acid, L1, was synthesized by the reaction of 2-amino-3- methylbutanoic acid and benzaldehyde along with its coordination compounds of with Cu(II) and Co(II) metal ions. The mixed ligand complexes of these compounds with ethane-1,2-diamine, L2, were also synthesized. shrimp was utilized to screen these compounds for their cytotoxic activity. To characterize the ligands, infrared and electronic spectroscopy were used. Magnetic susceptibility evaluations, percentage metal compositions, and electronic and infrared spectroscopy were used to characterize the synthesized complexes. The brine shrimp lethality assay was used to screen these compounds for their cytotoxic potential. The results obtained from the characterization indicated that a Schiff base was obtained. Furthermore, the complexes exhibited a variety of geometries from octahedral to square planar. The results obtained indicated that the compounds exhibited moderate cytotoxic activity.