Synthesis, Characterization and Antibacterial Activities of Mixed Ligand Metal(II) Complexes of Substituted Benzoic acid hydrazide and Isoniazid

Abstract

Mixed ligand metal complexes of substituted benzoic acid hydrazide and isoniazid were synthesized and characterized by percentage metal analysis, magnetic susceptibility, UV-Visible, IR spectroscopy and conductivity measurements. The infrared study revealed that the isoniazid and the hydrazide derivatives coordinated via the amino –NH₂ group and the carbonyl oxygen =C-O, acting as bidentate ligands with a reaction stoichiometry of isoniazid: hydrazides derivatives: metal chloride salt in the ratio 1:1:1. The observed magnetic moment revealed the paramagnetic nature of the complexes of mixed isoniazid and benzoic acid hydrazide derivatives (NH₂ or OH) with values of 3.18 and 3.69 BM for Co and 2.41 and 3.05 BM for Ni and 1.78 and 2.16 BM for Cu respectively. The conductivity results indicated that the complexes are non-electrolytic in nature while the UV-visible displayed several transitions characteristic of complexes in the octahedral geometry. The ligands and complexes were screened for antibacterial activities against eight strains of pathogenic bacteria. The results showed that the ligand displayed higher antimicrobial activities than the complexes.